Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal

Peer reviewedPublisher PD

Enzyme activity in terrestrial soil in relation to exploration of the Martian surface

Urease activity in soil is persistent for long periods under low water, low temperature, and sterile regimes, and it was suggested that some form of enzyme-protective mechanism exists in soil. Dublin soil was extracted by sonication in water followed by adding a mixture of salts. Urease activity is associated with the organo-mineral complex thus obtained and is resistant to the activities of proteolytic enzymes. Clay free soil organic matter prepared subsequently by filtration also exhibits urease activity which is resistant to proteolysis. Models consisting of enzymes with bentonite and lignin were found to mimic this resistance to proteolysis. A model system is presented which suggests both the origin and location of soil ureases and a reason for their persistence in nature

The Effects of Methylphenidate on Cognitive Control in Active Methamphetamine Dependence Using Functional Magnetic Resonance Imaging

Methamphetamine (MA) dependence is associated with cognitive deficits. Methylphenidate (MPH) has been shown to improve inhibitory control in healthy and cocaine-dependent subjects. This study aimed to understand the neurophysiological effects before and after acute MPH administration in active MA-dependent and control subjects. Fifteen MA-dependent and 18 control subjects aged 18–46 years were scanned using functional magnetic resonance imaging before and after either a single oral dose of MPH (18 mg) or placebo while performing a color-word Stroop task. Baseline accuracy was lower (p = 0.026) and response time (RT) was longer (p < 0.0001) for the incongruent compared to congruent condition, demonstrating the task probed cognitive control. Increased activation of the dorsolateral prefrontal cortex (DLPFC) and parietal cortex during the incongruent and Stroop effect conditions, respectively was observed in MA-dependent compared to control subjects (p < 0.05), suggesting the need to recruit neural resources within these regions for conflict resolution. Post- compared to pre-MPH treatment, increased RT and DLPFC activation for the Stroop effect were observed in MA-dependent subjects (p < 0.05). In comparison to MPH-treated controls and placebo-treated MA-dependent subjects, MPH-treated MA-dependent subjects showed decreased activation of parietal and occipital regions during the incongruent and Stroop effect conditions (p < 0.05). These findings suggest that in MA-dependent subjects, MPH facilitated increased recruitment of the DLPFC for Stroop conflict resolution, and a decreased need for recruitment of neural resources in parietal and occipital regions compared to the other groups, while maintaining a comparable level of task performance to that achieved pre-drug administration. Due to the small sample size, the results from this study are preliminary; however, they inform us about the effects of MPH on the neural correlates of cognitive control in active MA-dependent subjects

An Elementary Construction of Modified Hamiltonians and Modified Measures of 2D Kahan Maps

We show how to construct in an elementary way the invariant of the KHK discretisation of a cubic Hamiltonian system in two dimensions. That is, we show that this invariant is expressible as the product of the ratios of affine polynomials defining the prolongation of the three parallel sides of a hexagon. On the vertices of such a hexagon lie the indeterminacy points of the KHK map. This result is obtained analysing the structure of the singular fibres of the known invariant. We apply this construction to several examples, and we prove that a similar result holds true for a case outside the hypotheses of the main theorem, leading us to conjecture that further extensions are possible.Comment: 30 pages, 7 figure

Using discrete Darboux polynomials to detect and determine preserved measures and integrals of rational maps

In this Letter we propose a systematic approach for detecting and calculating preserved measures and integrals of a rational map. The approach is based on the use of cofactors and Discrete Darboux Polynomials and relies on the use of symbolic algebra tools. Given sufficient computing power, all rational preserved integrals can be found. We show, in two examples, how to use this method to detect and determine preserved measures and integrals of the considered rational maps.Comment: 8 pages, 1 Figur